It helps repair cells to reach damaged tissue
Elevated NNMT activitycommon in obesity and metabolic syndromedepletes NAD+ reserves by shunting nicotinamide into an excretory pathway rather than salvaging it for NAD+ biosynthesis
These signatures correspond to fatty acid metabolism, ketone and ketogenic/BCAA metabolism pathways
Clin Transl Med 14:e1744 Papadaki G, Goutakoli P, Tiniakou I, Grn JR, Grtzkau A, Pavlopoulos GA, Iliopoulos I, Bertsias G, Boumpas D, Ospelt C, Reizis B, Sidiropoulos P, Verginis P (2022) IL-6 Signaling Attenuates TNF- Production by Plasmacytoid Dendritic Cells in Rheumatoid Arthritis
Buijsse B, Lee DH, Steffen L, Erickson RR, Luepker RV, Jacobs DR Jr, Holtzman JL