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Similarly, the closed-state structures of GluK2 bound to the non-competitive inhibitor antiepileptic drug perampanel (Gangwar et al., 2023b), or polyamine blockers (Gangwar et al., 2024a), all solved in the presence of BPAM, displayed the same canonical two-fold symmetrical dimer-of-dimers arrangement of LBDs (Figures 7CF)

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Researchers have speculated that perhaps amino acids play a role through physiological mechanisms to prompt animals to take in an adequate supply of protein

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