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Glucagon-like peptide type 1 receptor agonistsIncretin effect and systemic effects of glucagon-like peptide type 1 and its agonists The incretin effect describes the phenomenon whereby oral glucose elicits higher (23 times) insulin secretory responses than does intravenous glucose.25 This is due to incretin hormones, such as GLP-1 or glucose-dependent insulinotropic polypeptide, which stimulate insulin secretion in response to food intake

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In addition, as an NADPH-dependent coenzyme Q (CoQ) oxidoreductase, apoptosis-inducing factor mitochondria-associated 2 (AIFM2) can use NADPH to catalyse the regeneration of CoQ10 and act synergistically with GPX4 and GSH to inhibit phospholipid peroxidation and ferroptosis [77, 78]