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2015;8(Spec Issue):43-46.

GHK-Cu exerts broad anti-inflammatory effects through its influence on approximately 31% of the human genome, specifically downregulating genes involved in inflammatory processes including interleukin-1, tumor necrosis factor-, and nuclear factor-B (NF-B) signaling while upregulating protective genes encoding antioxidant enzymes, DNA repair proteins, and anti-inflammatory mediators

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Additionally, a randomized trial showed a benefit in disease-free survival in breast cancer patients receiving presurgical peritumoral injection of lidocaine, which is also a VGSC inhibitor (331)