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While oral supplements are convenient, the first-pass metabolism in the digestive tract can break down the molecule before it reaches the bloodstream
10.1074/jbc.M705224200 Chiarugi P, Cirri P
Patients with autoimmune hypothyroidism who have appropriate indications such as type 2 diabetes or obesity may safely use these medications under medical supervision, provided they do not have a personal or family history of medullary thyroid carcinoma or MEN 2 syndrome
The high incidence and prevalence are attributed to the ageing population and poor lifestyles (Minari et al., 2023)
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