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Notably, interleukin-1 binds the IL-1 receptor type I and induces enzymes that degrade the extracellular matrix, including matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), thereby amplifying synovitis and initiating progressive cartilage loss (Li et al., 2021
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I was low in vitamin d, vitamin A, coQ10, and copper (all despite supplementation) and borderline in a dozen other intermediary metabolities
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