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This concern likely stems from a misunderstanding of how glutathione functions in the body

N Engl J Med (2019) 380:34757

Hypothyroidism, Cushing's syndrome, polycystic ovary syndrome (PCOS), perimenopause, obstructive sleep apnoea, or other hormonal imbalances may impede weight loss despite appropriate medication

However, the relevance of these findings to humans remains uncertain, as human thyroid C-cells have much lower expression of GLP-1 receptors compared to rodents

Although GLP-1 receptor agonists often lead to a decrease in fat mass and lean body mass during weight loss, recent clinical trials have confirmed that this does not necessarily have a negative impact on functional capacity