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In PD, harmful free radicals cause oxidative stress and cellular damage to the dopaminergic neurons
PMID: 24717514 View source Ulanovskaya OA, et al
An intact analysis method is preferred to avoid digestion, ensuring that precursor ions retain definitive molecular weight information
Oxidative stress also activates the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 to regulate the expression of genes that control antioxidant, inflammatory and immune system responses, facilitating GSH activity
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