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The same signal has been observed at high rates with Wegovy 7.2 mg, suggesting its an effect in the higher doses of GLP-1 medications rather than something specific to retatrutide

Soups, yogurt bowls, and eggs work best during the peak side effect window

The FDA's prescribing information for Wegovy lists the option to delay dose escalation by 4 additional weeks at any tier if GI tolerability is a concern [15]

Conversely, they activate the NLRP3 inflammasome, promoting a pro-inflammatory response in inflammatory contexts