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However, significant fluid retention could potentially elevate blood pressure, so its a variable that should always be monitored closely

By applying a few practical strategies, clinicians can reduce risks while maintaining treatment benefits

These are mechanistic observations within experimental systems, not claims about human physiology

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In AD mouse models, semaglutide increased the expression of SIRT1 and its downstream target, glucose transporter GLUT4, thereby enhancing glucose uptake and rectifying glycolytic deficits in the hippocampus (Athauda et al., 2026)