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However, from 8 weeks of pregnancy to term, free hCG- is 1% or less of the total hCG- immunoreactivity in serum.58, 59, 60 Metabolism and Clearance of hCG and Its Subunits The clearance of holo-hCG from the circulation has two components: a fast component (approximately 7 hours) and a slow component (approximately 39 hours).65 The half-life of holo-hCG is considerably longer than that of LH, primarily because of the glycosylated C-terminal peptide of the subunit

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