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Pharmacological treatment of obesity is associated with post-cessation weight regain or weight cycling a further concern in the context of sarcopenia

[5] The incidence of arthralgia in many trial populations taking GLP-1 medications has generally been similar to placebo groups , though this varies by product

GLP-1 receptor activation reduces food intake by both peripheral satiety signaling and direct central appetite suppression

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The FDA ruled in favor of Novo Nordisk, stating that the company had demonstrated adequate availability of its brand-name products to meet patient demand