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The current study identified chloride channel (ClC)-family proton/chloride antiporters as a modulator in the process of histamine production (Hall et al., Lactobacillus reuteri 6475 is special among gut microbes due to it containing a complete chromosomal histidine decarboxylase ( hdc ) gene cluster (genes hdc A, hdc B, and hdc P) and thus having the genetic capacity to convert histidine to histamine (Spinler et al., 2014)