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The margin for error is razor-thin: MT-1 activates melanocortin receptors (MC1R, MC3R, MC4R, MC5R) at specific concentration thresholds, and overshooting by even 0.2mg can trigger receptor-mediated side effects that derail research protocols entirely

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With a growing number of patients using these medications for diabetes or to meet certain optimization goals before undergoing hip and knee reconstructive surgery, our aim was to establish evidence-based guidelines on when to discontinue these to enhance patient safety and surgical success. The study, Optimal Timing for Cessation of GLP-1 Agonist Before Elective Total Hip and Knee Arthroplasty, obtained data from the TriNetX Research Network, a multi-institutional national aggregated database, to identify patients who underwent TKA or THA from January 1, 2018 to January 1, 2023

These hormones can be released in the blood or activates the vagal afferents nerves, thereby targeting the brain (Figure 1)

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