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This idea has been corroborated by previous research that demonstrated the systemic metabolic advantages of SGLT2 inhibitors in diabetic animals

doi: 10.1093/femsec/fiz187 56 HamillR

GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats
doi: 10.1210/jc.2003-031403 18 HanF.HouN.LiuY.HuangN.PanR.ZhangX.et al

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