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We next analyzed the time spent in the center zone and the peripheral zone in the OFT and observed that Ex-4 produced anxiogenic effects in SPF mice, while Ex(9-39) had no effect on ABX mice (Supplementary Fig
This could allow higher therapeutic doses of GLP1 analogs to be administrated with fewer side effects [75]
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This personalized approach helps separate genuine genetic vulnerability from simple caloric deficit stress
A similar mechanism is available in countries such as the US, Japan and Australia, termed Patent Term Extensions (PTEs)
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