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Whereas creatinine-based estimates of GFR are able to predict risks associated with declining kidney function when eGFR levels fall to 60 mL/min/1.73m2 or less, GFR estimates based on cystatin C level are predictive at approximately 85 mL/min/1.73m2

The only sign is reduced efficacy (weight loss stalls, appetite suppression weakens)

If side effects continue, switching to a different weekly injectable option may help

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Semaglutide is a prescription medication approved by the FDA to help manage type 2 diabetes (Ozempic) and to support long-term weight loss (Wegovy)