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Similar to the periplasm, the GSH:GSSG ratio in the ER is lower (3:1 to 1:1) compared to the cytosol (100:1), resulting in a more oxidizing environment (Hwang et al., 1992)
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The endpoint algorithms were validated and showed a sensitivity of over 99% for mortality in the National Death Index, a positive predictive value of 94% for myocardial infarction, 95% for stroke and 98% for heart failure hospitalization 33,35,36,37,38,39,40
In persons with normal weight, the contribution of fat-free mass loss often exceeds 35 percent of total weight loss, and weight regain promotes relatively more fat gain
Those findings might explain the reduction of aortic plaques areas independent of body weight changes by semaglutide and liraglutide in this study
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