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Dual agonists, like Survodutide and Tirzepatide, target two metabolic pathways simultaneously, offering potentially greater efficacy in treating conditions like MASH compared to single-target GLP-1 agonists, which focus on just one pathway
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doi: 10.1002/hep.28431 35
Since the mean/median duration for each of these studies was 100,000 patients prescribed a GLP-1RA, after propensity matching, there was reduced risk for PDAC during a 5-year observation period for GLP-1RA users compared to six categories of commonly used diabetes medication classes 44
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