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Target trial emulation for observational studiespotential and pitfalls
The ACR Convergence 2025 data, the Sjogren case report, the CRP reduction data from STEP and SELECT trials
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However, if the ER stress is prolonged or excessive, ER UPR can ultimately lead to cell death via apoptotic pathways (115, 116)
Their use can be proposed as alternatives for patients who may not undergo surgery, as a bridge to optimize outcomes before or in association with surgery
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