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Figure 10: High homocysteine (HHcy) levels can damage multiple organs by producing toxic byproducts from cysteine and methionine

Dopamine -hydroxylase is a major vitamin C and copper (Cu 2+ )-dependent enzyme whose activity is negatively affected in Menkes disease

This is especially true with protein-rich meals, as amino acids may interfere with glutathione uptake

and actually SARS-CoV-2 causing COVID-19, all are characterized by persistent inflammation, continuous production of reactive oxygen/nitrogen species and oxidative stress that predominate over the antioxidant defenses (GSH and free radical scavenger enzymes) resulting in cell/tissue/organ aging associated with early (premature) chronic inflammation/inflammaging. We propose that, although inflammaging was introduced for the aging process (276289), it could also apply to early (premature) tissue and organ aging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses, especially low GSH levels, in younger individuals

29 Diarrhea is further classified as acute or chronic, based on its onset and duration