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However, in line with the specificity of CPA, the C-terminal residues of the L585I, L585M, and L585V variants were cleaved in vitro upon exposure to the enzyme for 5 hours at 37 C, as confirmed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis of the C-terminal peptides (Supplementary Table 1)

Demonstrates how multi-omics integration strengthens disease research, complementing the GSH/GSSG framework with proteomic and lipidomic context for metabolic and inflammatory stress conditions

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A separate regulatory status This is the major asymmetry between the two