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4 Adverse events in PIONEER 3 1,4 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Because clinical trials are conducted under widely varying conditions, AE rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 AE=adverse event

Immunohistochemical analysis of tissue was used to determine any neuroprotective effects on the CNS

Recent advances in primary and secondary prevention of atherosclerotic stroke

Having a strategy in place before stoppingsuch as transitioning to a lower maintenance dose or structured lifestyle supportsignificantly reduces rebound risk

(Cochrane Metabolic and Endocrine Disorders Group) (June 2020)