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First, the sulfonation reaction saturates and that allows more NAPQI to accumulate ([7, 24]) and second, the increased amount of NAPQI exhausts the liver stores of reduced glutathione (GSH)[6] as well as the livers capacity to synthesize new GSH
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We explored whether the glutathione cycle can complement the actions of the glutamate-glutamine shuttle by blocking import of glutamine by the system A transporter (15), which imports glutamine into neurons, after which it is converted to glutamate (Fig
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