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However, their limited ability to cross the BBB (under 6%) hinders routine formulations from achieving therapeutic concentrations in the brain, significantly restricting their clinical applicability 13

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Cell Mol Life Sci (2004) 61:27207.10.1007/s00018-004-4243-4 22 VauquelinGMichotteYSmoldersISarreSEbingerGDupontAet alCellular targets for angiotensin II fragments: pharmacological and molecular evidence