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Executive Director Shabbir Imber Safdar argued that the committee's decision is "a serious setback for patient safety," warning that it could legitimize compounds lacking adequate clinical evidence and increase the spread of potentially unsafe products through wellness clinics, medical spas, and online platforms

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Addressing these fundamental challenges is essential for successful clinical translation

Phase I consist primarily of microsomal enzymes, which are found abundantly in the liver, gastrointestinal tract, lung and kidney, consisting of families and subfamilies of enzymes that are classified based on their amino acid sequence identities or similarities