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Acknowledgements The authors thank J

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TM16-TM17 of MRP1 are essential for the stimulated transport of GSH and collateral sensitivity Since MRP1/MRP2 chimeras were differently impacted in their activities of resistance to drugs co-transported with GSH, we therefore looked at the persistence or disappearance of the activity of the stimulated transport of GSH and collateral sensitivity of the FlpIn 293 expressing MRP1, MRP2 or the chimera to CS agents including verapamil, a well-established CS agent we used as a reference compound