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2025 Dec;333(Pt 1):148831

Both agents affect insulin sensitivity and glucose regulation, creating unpredictable risks including glucose dysregulation when used together

In a new interview with People, published Friday, the 46-year-old explained that December 2025 was a rough month for her due to a side effect of semaglutide

Tirzepatide, a dual glucagon-like peptide-1 (GIP) and GLP-1RAs, administered once weekly at a 15 mg dose, resulted in an average weight loss of 20.9% over 72 weeks (Jastreboff et al., 2022), driven by its synergistic effects on appetite regulation, energy intake reduction, and fat mass decrease (Heise et al., 2023)

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