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Summary: Feeling cold on retatrutide is most likely caused by rapid weight loss and reduced caloric intake rather than a direct drug effect on thermoregulation
Insufficient time on therapeutic dose is another frequent issue
Tan says the 12 percent increase in gout risk reported in the study is a significant increase. Its possible GLP-1s could lead to temporary changes in uric acid level because of shifting fat-muscle ratios, she says
The ideal choices share several characteristics: they promote muscle preservation during caloric deficit, they enhance rather than impair fat oxidation, they produce minimal water retention, and they have manageable side effect profiles when used responsibly
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