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A review of 11 studies found that lactitol supplements helped improve constipation symptoms and were well tolerated (20)
Local NHS formularies and NICE guidance will influence which treatments are available through the NHS
Cortisol responses may vary depending on fasting duration, circadian rhythm, stress levels, sleep quality, and population characteristics, yet these variables are often underreported [45, 46]
Drug repurposing offers a promising and expedited strategy to address these conditions
Meanwhile, long-term intracellular accumulation of platinum ions and persistent oxidative stress can activate the senescence program of renal tubular epithelial cells, induce cell cycle arrest and Senescence-Associated Secretory Phenotype (SASP), release a large number of pro-inflammatory and pro-fibrotic factors through paracrine effects, further amplify the local inflammatory response, and activate the proliferation and activation of renal interstitial fibroblasts (Nakao et al
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