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Regradless of FMO3 capacity, while TMA is in the bloodstream it is filtered out via the kidneys (95% over 24 hours [20] ) to the bladder, and slowly exits the body in bodily fluids

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Regarding GSH, numerous research work verified the effectivity of this tripeptide as BBB targeting ligand of various vesicular [52,53,54] and poly(lactic- co -glycolic acid) (PLGA) nanoparticles [55, 56] in cell culture models, animals and in human studies as well