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It has been observed that vitamin B12 also has antioxidant effects when it gets absorbed, and it is used as a cofactor for enzymes that are involved in the synthesis of deoxyribonucleic acid (DNA), fatty acids, and myelin

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The metabolic syndrome and Alzheimer disease

Thus, CHAC1 serves a dual role: it preserves mitochondrial function by ensuring a cysteine supply under nutrient stress, but it also facilitates ferroptosis by maintaining ETC activity, highlighting its potential as a therapeutic target in cancer treatment (Ward et al., 2024)

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