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5.4 Modulation of the PI3K/AKT/PTEN survival and metabolic pathway The PI3K/AKT/PTEN axis integrates metabolic control, cell survival, and growth factor responses in reproductive tissues (Matsuda et al., 2013)
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Human growth hormone (HGH), produced by the anterior pituitary gland, plays a central role in: Body composition: GH promotes fat breakdown (lipolysis) and supports lean muscle preservation Tissue repair: GH stimulates collagen synthesis, wound healing, and cellular regeneration Sleep quality: GH is primarily released during deep (slow-wave) sleep Bone density: GH works alongside IGF-1 to maintain bone mineral density Immune function: GH supports immune cell proliferation and activity Cognitive function: GH receptors are present throughout the brain Growth hormone production declines approximately 14% per decade after age 30, a process sometimes called somatopause
