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People who feel they lose weight after starting B12 are usually correcting a deficiency that left them tired and inactive, so they simply move more once their energy returns
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However, scientific research shows that very high-dose oral B12 (1,000-2,000 mcg) can be effective for some, as about 1% can be absorbed without intrinsic factor
Transcobalamin carries the smaller remaining share, and that is the fraction cells can absorb and use
It is also in the process of being investigated for a variety of other purposes
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