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Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma

As shown in Scheme 12

1 2 "Comparison of the sensitivity and specificity of six immunoassays for the detection of amphetamines in urine"

CMAJ 192 , E875E891 (2020)

Similar effects have been demonstrated in osteoarthritis models, where liraglutide facilitates macrophage polarization toward the anti-inflammatory M2 phenotype by downregulating M1-associated markers such as Mcp-1 and Cd38, while upregulating M2-related genes including Erg-2, reducing the secretion of pro-inflammatory cytokines and mitigates inflammatory responses (Meurot et al., 2022)