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found that subchondral injection of bone marrow-derived MSCs is significantly more effective than intra-articular delivery in delaying total knee arthroplasty (TKA), with a 15-year randomized trial showing a 70% TKA rate in knees treated intra-articularly versus only 20% in those treated subchondrally (Hernigou et al., 2021a)
From a strategic perspective, METRNL illustrates the limitations of purely receptor-centric approaches to peptide drug discovery
Asmar, A
L., Grailhe R., Dawson T
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