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First, a broad, non-selective molecule that opened up the exploration of the melanocortin system and remains the gold standard for studying pigmentation via the MC1R

Serious but Rare Side Effects: Increased blood pressure, seizures (particularly in patients with eating disorders), and thoughts of suicide

The BCPNN analysis further validated these findings, demonstrating that female patients had higher risks of long-term treatment-related adverse reactions, whereas male patients experienced more acute adverse events in the short term

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