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GLP-1s are contraindicated in individuals with a history of medullary thyroid carcinoma, a family history of such, or in patients with multiple endocrine neoplasia syndrome type 2
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At the cellular level, vitamin D3 attenuated doxorubicin-induced senescence in human aortic endothelial cells by upregulating IL-10 and FOXO3a expression through the pAMPK/SIRT1/FOXO3a signaling pathway [180]
One more clinical note: the trial used a gradual titration protocol specifically to manage tolerability
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