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6 Although metformin is usually an effective treatment for regulating glucose levels, many patients with T2D have an elevated risk of cardiac events that does not improve in response to metformin

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N Engl J Med 373:21172128 Neal B, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Erondu N, Shaw W, Law G, Desai M, Matthews DR (2017) Canagliflozin and cardiovascular and renal events in type 2 diabetes