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Any perceived energy increase results indirectly from improved blood sugar control, weight loss, and resolution of obesity-related symptoms rather than pharmacological stimulation
Specifically, SGLT2 inhibitors were associated with an increased risk of UTIs compare to non-Asian patients, but the risk of UTI was similar to placebo in Asian patients (56)
Extensive research on intestinal flora in recent years has shown that bacterial translocation and the existence of bacterial active products in the blood circulation can aggravate the inflammatory state of the whole blood vessel
To put this in perspective, to justify their current valuation, they only have to grow their topline by ~7% for eight years while the overall obesity care market is expected to grow by ~26% CAGR
Some clinical experts and recent Phase 3 reporting have also noted that weight loss in some participants has been substantial enough to raise questions about how much weight loss may be too much, particularly when these medications are used outside tightly controlled medical settings and without provider supervision
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