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Biochem J 215: 441445
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Overall, these findings show that GLP-1R recycling is influenced by persistence of agonist binding within the endosomal compartment, resulting in enhanced insulin-releasing properties of fast-dissociating agonists which maintain an adequate population of cell surface receptors over prolonged periods
introduced a new series of (R)-3-amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl) butan-1-one analogs as a novel class of DPP-4 inhibitors
This was performed using the optical disector to estimate Ionized calcium-binding adapter molecule 1 (IBA1)-positive microglia cells and Glial fibrillary acidic protein (GFAP)-positive astroglia cell densities (Fig
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