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or for patients with diabetes and at high risk of liver fibrosis, as there are potential beneficial effects on MASLD.(4) Studies of GLP-1 RA Use in Patients with Cirrhosis A retrospective study in Taiwan, using matched pairs in which half of the patients used GLP-1 RAs, and the other half did not, included patients with type 2 diabetes and compensated cirrhosis

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Exposure of the liver to xenobiotic substances means the body prepares itself by increasing detoxification enzymes, i.e., cytochrome P-450 mixed-function oxidase

At the same time, Medicares drug price negotiation program is expected to introduce lower negotiated prices for certain GLP-1 medications: Semaglutide negotiations expected in 2027 Dulaglutide negotiations expected in 2028 These price adjustments could offset some of the spending increases tied to broader access