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Improvement in blood pressure was also reversed
While there are no head-to-head trials specifically designed to compare tirzepatide plus metformin versus tirzepatide alone for weight loss, the available evidence suggests the combination is safe and effective, with metformin providing additional metabolic benefits without diminishing tirzepatide's weight loss effects
Another possibility is the existence of differences in the effect of high molecular weight versus low molecular weight peptides on GLP-1R signaling in the CNS [23]
Mayerson, A
And Im doing it because of the drugs
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