QC: Validation, Writing original draft
Under arsenite stress, this METTL3/YTHDF2 interaction is inhibited, which stabilizes CHAC1 mRNA and increases its expression ( In addition to arsenite-induced expression, the CHAC1 gene is transcriptionally activated during cysteine, serine or arginine depletion (Ward et al., 2024)
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In the mitochondrial pathway, H 2 O 2 increases calcium ion concentrations within the mitochondria [77], regulates Bcl-2 family protein expression and activity, leading to decreased mitochondrial membrane potential, cytochrome c release, and ultimately triggering apoptosis [78]
k , Immunoblot of SLC25A39 and ATF4 proteins in HeLa cells treated with indicated doses of mitoCDNB, diamide and BSO (1 mM)/erastin (5 M) for 24 h