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Do the cramps get worse with higher doses
February 7, 2010
Alprostadil: Prostaglandin E1 analog that activates EP2/EP4 receptors on corpus cavernosum smooth muscle, increasing cAMP to produce direct vasodilation and erection independent of CNS arousal or desire signaling
Intramuscular injection would cause too-rapid absorption and is not recommended
Research comparing routes of administration is ongoing and findings are mixed, so the practical difference for any individual patient is a question for their prescribing provider
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