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Chemically, trimethylamine and similar volatile amines are the main culprits

Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity

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Therefore, HLA-DR2 could have a negative effect on the antiviral T cell responses different pathogens, preventing control of the initial viremia and leading to increased viral persistence and higher antibody titers (104, 121, 122)