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doi: 10.3389/fpsyt.2021.669089 Received 17 February 2021 Accepted 16 August 2021 Published 30 September 2021 Volume 12 - 2021 Edited by Francesca Bonomini, University of Brescia, Italy Reviewed by Mostafa Waly, Sultan Qaboos University, Oman

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Resistance training (light to moderate intensity) Prioritize protein at all meals Take all morning supplements with breakfast Prepare electrolyte water bottles for the week Walk 20 to 30 minutes, preferably morning Track food intake to ensure meeting minimums Evening: magnesium supplement, limit screens one hour before bed Resistance training (light to moderate intensity) Post-workout protein shake Afternoon: healthy snack if energy drops Early dinner to allow digestion before bed Rest day or gentle yoga only Focus on hydration throughout the day Prepare meals for upcoming days if helpful Stress management activity in evening Resistance training (light to moderate intensity) Injection day for many patients, choose timing that works for you Earlier bedtime if injection causes next-day fatigue Longer walk or recreational activity Allow flexibility in meal timing Catch-up sleep if needed, but maintain general schedule Rest day Meal preparation for the week Review supplement supplies, reorder if needed Set intentions for the upcoming week Strategy 18: Warning Signs That Need Medical Attention While fatigue during Retatrutide treatment is common and usually manageable, certain symptoms warrant medical evaluation

How PlexusDx Supports a More Personalized Approach PlexusDx's Precision Peptide Genetic Test evaluates predispositions in key metabolic pathwaysincluding GIPR rs1800437, and MC4R rs17782313 variantsthat may influence how individual patients respond to GLP-1 therapy and weight regulation