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confirmed an increase in skin thickness in the range of the epidermis and dermis, improved skin hydration, a significant smoothing of the skin by stimulating collagen synthesis, increased skin elasticity, a significant improvement in skin contrast, and an increased production of collagen I

VEGF upregulation, for example, is also associated with pathological angiogenesis

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Subcutaneous injection bypasses the penetration problem entirely but delivers the peptide systemically rather than locally