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More serous B12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serous symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia, and changes in reflexes

A study of nearly 28,000 23andMe users who reported taking GLP-1 weight-loss medications, published in Nature, found that a mutation in GLP1R, the gene encoding the protein targeted by GLP-1 drugs, was modestly but significantly associated with greater weight loss

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