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Please see the Important Safety Information, Full Prescribing Information, and Healthcare Provider Counseling Tool for Patients of Reproductive Potential for Qsymia

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Hegarty et al., 2018)

In preclinical research models, MOTS-C has been shown to translocate to the nucleus in response to metabolic stress, where it regulates the expression of antioxidant and metabolic response genes

Both sorafenib and sulfasalazine are FDA approved drugs that have been shown to induce ferroptosis and inhibit tumor growth, however, in addition to inhibiting SLC7A11, sorafenib acts as a multi-kinase inhibitor and sulfasalazine blocks prostaglandin production (136, 137)